Is it true that for any integral domain $D$ , $\text{Frac}(D)[x] \cong \text{Frac}(D[x])$?

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Is it true that for any integral domain $D$ , $\text{Frac}(D)[x] \cong \text{Frac}(D[x])$ ? , where $\text{Frac}$ denotes the fraction field of the integral domain . I am at a complete loss, please help. Thanks in advance.

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Is $Frac(D)[x]$ always a field? Is $Frac(D[x])$ always a field? Note the first one has the form $R[x]$ and the second one $Frac[S]$, with $R$ and $S$ rings.