$\color{crimson}{\text{Problem}}$
Show that if $f:\mathbb{R}\to\mathbb{R}$ be a polynomial of odd degree with real coefficients then it has at least one real root.
$\color{green}{\text{Proof}}$
Let $$f(x)=a_{2n+1}x^{2n+1}+a_{2n}x^{2n}+\ldots+a_1x+a_0$$ be a polynomial where $a_i\in\mathbb{R}$ for all $i\in \{1,2,\ldots,2n+1\}$ and $a_{2n+1}\ne 0$. Without loss of generality we can also assume that $a_0>0$. Then, $$\boxed{f(0)>0}$$
Case 1
Let $a_i\ne 0$ for all $i\in \{1,2,\ldots,2n+1\}$. Then we rewrite $f(x)$ as,
$$f(x)=x^{2n}\left(a_{2n+1}x+a_{2n}\right)+\ldots+(a_1x+a_0)$$Now observe that the sign of the terms of the form $x^{2i}\left(a_{2i+1}x+a_{2i}\right)$ depends only on the sign of $\left(a_{2i+1}x+a_{2i}\right)$. So, if we want to show that $f(x)<0$ for some $x\in\mathbb{R}$, it suffices to show that each terms of the form $\left(a_{2i+1}x+a_{2i}\right)<0$. This arguments shows that $f(x_0)<0$ for any $x_0\in \mathbb{R}$ such that, $$x_0<\min\left(-\dfrac{a_{2n}}{a_{2n+1}},-\dfrac{a_{2n-2}}{a_{2n-1}},\ldots,-\dfrac{a_{0}}{a_{1}}\right)$$
Case 2
If on the other hand $a_{2i+1}=0$ for some $i$'s (if $a_{2i}$'s are $0$, it won't affect the argument of Case 1) then we define the polynomial $g:\mathbb{R}\to\mathbb{R}$ defined by, $$g(x)=b_{2n+1}x^{2n+1}+b_{2n}x^{2n}+\ldots+b_1x+b_0$$ where, $$b_{2i+1}\begin{cases}=-1 & \text{if}\ a_{2i+1}=0\\=a_{2i+1} & \text{if}\ a_{2i+1}\ne0\end{cases}$$Then, to the polynomial $g(x)$, the argument of Case 1 applies.
Now for this $g(x)$ we choose $x_0$ is such a manner that $x_0<0$. Then $g(x_0)<0$ and also $g(x_0)>f(x_0)$. Consequently $f(x_0)<0$
What is left now is to apply Bolzano's Theorem to conclude the existence of a root.
It might not be possible to find an $x$ such that all the $a_{2i+1}x + a_{2i}$ are negative. The interval you suggested, $x < \min -\frac{a_{2i}}{a_{2i+1}}$, is not valid because $a_{2i+1}x < -a_{2i}$ does not imply $x < -a_{2i}/a_{2i+1}$. The direction of the inequality changes when you divide by a negative number. So, sometimes, your argument will need $x$ to be bigger than some things and smaller than others. This may not always happen: as in André's example $x^3 - x^2 - x + 2$, you would want $x - 1 < 0$ and $-x + 2 < 0$, i.e. $x < 1$ and $x > 2$. No such $x$ exists!