We know that for (a normal) domain $-\Delta:H^1_0(\Omega) \to H^{-1}(\Omega)$ is an isomorphism.
What is the corresponding result for the Laplace-Bulltrami operator or more generally a Laplacian operator on a manifold which has no boundary? What properties does it satisfy?
It holds also on sufficiently smooth Riemannian manifolds, and in fact for more general partial differential operators (even pseudo-differential operators.)
See for example Hebey, Nonlinear Analysis on Manifolds: Sobolev Spaces and Inequalities.