I found myself wondering whether the Rubik's Cube group (of order $2^{27} \cdot 3^{14} \cdot 5^3 \cdot 7^2 \cdot 11$) is normal as a subgroup of the slightly larger group where assembly/disassembly of the cube is allowed (of order $2^{29} \cdot 3^{15} \cdot 5^3 \cdot 7^2 \cdot 11 = 12! \cdot 8! \cdot 2^{12} \cdot 3^8$).
Most of the parity restrictions are easy enough to cast as kernels of group homomorphisms: the restriction on cubie placement can be interpreted as taking a group homomorphism from the larger group to $S_{20}$, and then composing with the sign homomorphism to $\{ \pm 1 \}$, and taking the kernel. Similarly, the edge orientation restriction can be interpreted as taking a group homomorphism from the larger group to $S_{24}$ (taking the corresponding permutation of edge stickers), and then again composing with the sign homomorphism to $\{ \pm 1 \}$, and taking the kernel.
What's left is the restriction on corner orientation. I have seen descriptions of corresponding functions from the larger group to $\mathbb{Z} / 3 \mathbb{Z}$; what is not clear to me is whether any of these functions gives a homomorphism of groups. (And in trying to apply the definition of normality directly, I have a hard time working with disassembling/reassembling the cube, applying some sequence of face rotations, and then applying the inverse of the original disassembly/reassembly.)
Let $G$ be the usual Rubik's cube group, and $G_0$ be the full disassembly group. Yes, $G$ is a normal subgroup of $G_0$.
It is clear that $G_0$ breaks up into a direct product $G_0^{c} \times G_0^{e}$ ($c$ for corners, $e$ for edges). $G_0^c$ are the permutations that only move corner pieces, and $G_0^e$ are the permutations that only move edge pieces.
Now $G_0^c$ has a normal subgroup $N^c$ which fixes the position, but not necessarily the orientation, of each corner piece. It is clear that $N^c \cong (\mathbb{Z}/3\mathbb{Z})^8$. I claim that $N^c$ has a complement $K^c$ in $G_0^c$ isomorphic to $S_8$. To see this, fix one reference sticker on each corner piece, for example, all the U and D stickers on corner pieces. There are 8 reference stickers, one per corner. Consider the subgroup $K^c$ of elements of $G_0^c$ which take reference stickers to reference stickers. If all reference stickers are fixed, then all remaining corner stickers are fixed too. Therefore $K^c \cong S_8$. We conclude that $G_0^c \cong N^c \rtimes K^c$ (semidirect product).
In the same way, $G_0^e \cong N^e \rtimes K^e$.
Now $G$ can be described as the intersection of these three normal subgroups of $G_0$:
(1) Corner condition. Consider the sequence of maps $G_0 \to G_0^c \to N^c \cong (\mathbb{Z}/3\mathbb{Z})^{8} \to \mathbb{Z}/3\mathbb{Z}$ (the first 2 maps are projections and the last one is the sum of the 8 components). Now we have to be careful. The second map $G_0^c \to N^c$ is not a homomorphism. Instead it satisfies a cocycle equation $\phi(gh) = \phi(g) + g\phi(h)g^{-1}$ (it's possible that $g$ and $g^{-1}$ need to be switched here, depending on your conventions). However, when you sum both sides of this cocycle equation over the 8 components, the twist in the last term cancels out and so the combined map is a homomorphism. (This last part is explained in full detail here, parts II and III, without saying the word "cocycle".) Its kernel gives the elements of $G_0$ that satisfies the "corner twist" condition.
(2) Edge condition. In a similar way, you get a normal subgroup of $G_0$ consisting of all elements satisfying the "edge twist" condition.
(3) Parity condition. We project $G_0 \to K^c \times K^e \cong S_8 \times S_{12}$ (which is a homomorphism) and take those elements of $G_0$ whose images are (odd, odd) or (even, even) in $S_8 \times S_{12}$.
Since $G$ is the intersection of these 3 normal subgroups of $G_0$, then $G$ is a normal subgroup of $G_0$.