Assume I want to solve $$ u^4 + \alpha u^2 + \beta u + \gamma = 0 $$ (only real-valued solutions are needed) for real $\alpha, \beta, \gamma \in \mathbb R$, $\beta \ne 0$ and assume I have already found a $y\in \mathbb R$ such that $$ y^3 + \frac 5 2\alpha y^2 + (2\alpha^2 - \gamma) y + \bigg( \frac {\alpha^3} 2 - \frac {\alpha \gamma} 2 - \frac {\beta^2} 8 \bigg) = 0. $$ Does this imply $\alpha + 2 y \ge 0$?
I am asking because, as a next step, Wikipedia suggests to solve two quadratic equations in $u$, which contain $\sqrt{\alpha + 2 y}$.
If not, is there another method of solving the original quartic equation in $u$ with only real numbers involved?
Whether $\sqrt{\alpha+2y}$ is real is less important than recognizing that complex coefficients present no issue with solving quadratic equations. The quadratic formula may give a square root of a complex number, true; but that (unlike cube roots and higher prime-order roots) can be solved by algebra alone. See, for instance, this very informative answer on how to do it.
If the resolvent cubic given in the question has three real roots, then not all can give positive values of $\alpha+2y$ for positive $\alpha$. For the three real roots satisfy
$y_1+y_2+y_3=-(5/2)\alpha$
And thus
$(\alpha+2y_1)+(\alpha+2y_2)+(\alpha+2y_3)=3\alpha-5\alpha=-2\alpha$
which is negative for positive $\alpha$, from which st least one of the $\alpha+2y$ addends must also be negative.