Does there exist a complete set of topological invariants for smooth 3-manifolds? (If not for all smooth 3-manifolds, maybe for a certain class?)
By equipping the manifold with a metric, can some invariants be expressed in terms of the metric? For example, in 2d, the genus can be expressed as the integral of the Riemann curvature, due to the Gauss-Bonnet theorem.
There exist various ways of classifying $3$-manifolds, but the result is nowhere near as simple as the one for closed $2$-surfaces, where orientability and genus (or, equivalently, $H^1$) give a full classification. Like $2$-manifolds, though, the smooth, continuous, and PL categories are all equivalent in dimension $3$. I'm also going to be considering only the oriented, closed case below.
These are some of the main types of classification, but the subject of $3$-manifolds gets technical very quickly and relies on many nontrivial results from both algebraic and geometric topology. If you're new to the subject and want something that's interesting but doesn't require as long of a wind-up to get to the results, take a look at Mostow rigidity for hyperbolic manifolds. It has the same flavor of "metric invariants are secretly topological invariants" as Gauss-Bonnet, and it often pops up in $3$-manifold geometry.