In Basic Topology (Armstrong, M.A., 1983) we have the following:
(5.13) Theorem. If $G$ acts as a group of homeomorphisms on a simply connected space $X$, and if each point $x \in X$ has a neighbourhood $U$ which satisfies $U \cap g(U) = \emptyset$ for all $g \in G - \{e\}$, then $\pi_1(X/G)$ is isomorphic to $G$.
Probably a very naive question, but is there a version of this without the assumption of simply-connectedness that gives us a (mere) homomorphism $\pi_1(X/G) \rightarrow G$? If so, how is this homomorphism defined?
I think that deck transformations are relevant here, but my understanding of them is a bit sketchy and I'm having trouble pulling my intuitions together into a coherent thought.
This question is related, but seems to go the other way.
To get a morphism you would first need a "concrete group" not just an isomorphism class, that is,you'd need to fix a point in $X/G$, say $x_0$.
For the morphism you'll also need a specific preimage of $x_0$, say $a_0\in X$
Then what you can see is that $p:X\to X/G$ is a covering map. So given $[\alpha]\in \pi_1(X/G, x_0)$, you can see it as a loop $\alpha$ and lift this to a path in $X$, with beginning and end points in the same orbit, say $a_0, a_1, a_1 = g\cdot a_0$.
Then you can use the hypothesis and see that $g$ is actually the only member of the group that sends $a_0$ to $a_1$, and actually it's the only (provided $X$ is connected - though not necessarily simply connected) automorphism of the covering sending $a_0$ to $a_1$. So you can define the image of $[\alpha]$ as $g$; see that this is well-defined and a morphism $\pi_1(X/G, x_0) \to G$.
In the general case, this won't be injective though of course if $X$ is path-connected (still no assumption of simple-connectedness though) it will be surjective.
In this case the kernel of this map is $p_\star(\pi_1(X, a_0))$, and so you get an isomorphism $\pi_1(X/G, x_0)/p_\star(\pi_1(X, a_0)) \simeq G$. This is exactly what you have when $X$ is simply connected, but here it's a bit more general.