The GCH axiom basically says that for all infinite cardinal numbers $\kappa$, the number of cardinals lying strictly between $\kappa$ and $2^\kappa$ is as small as possible. Namely, there are none.
Is there an axiom which claims the opposite, in other words that the number of cardinal numbers lying strictly between $\kappa$ and $2^\kappa$ is as large (in some sense) as possible?
Edit. For example - and I don't know if this is a silly suggestions, I know very little set theory - is the following axiom for infinite cardinals $\kappa$ consistent with ZFC? And if so, is it interesting? $$|\{\mbox{cardinals } \nu \mid \kappa<\nu<2^\kappa\}|=2^\kappa$$
Note that there is no "largest possible distance" between even $\aleph_0$ and $\mathfrak{c} = 2^{\aleph_0}$. It is an old result that as long as $\aleph_\alpha$ has uncountable cofinality, then it is relatively consistent with $\mathsf{ZFC}$ that $\mathfrak{c} = \aleph_\alpha$. As every infinite successor cardinal has uncountable cofinality, this implies that there is no bound on the number of cardinals strictly between $\aleph_0$ and $\mathfrak{c}$.
Easton's Theorem goes even further, and says that except for certain basic restrictions, the function $\aleph_\alpha \mapsto 2^{\aleph_\alpha} = \aleph_{G(\alpha)}$ restricted to the regular cardinals can be pretty much arbitrary. (As Andrés Caicedo notes in his comment below, under the assumption of certain large cardinal hypotheses, the arbitrariness is further restricted. As a basic example, the least (infinite) cardinal at which $\sf{GCH}$ fails cannot be measurable.)
The answers to these questions might also be of interest: