I would like to prove that for any $k\in \mathbb{N}$, there is a unique polynomial of $2k +1$ degree, $p(x)=a_{2k+1}x^{2k+1}+\dots+a_0$ such that $p(0), p'(0),\dots p^{(k)}(0)$ and $p(1), p'(1),\dots ,p^{(k)}(1)$ are given. For the cases $k=0,1,2$ it is fairly easy to prove that as it ends up to a linear system. But how about the general case ? So after some handling (developing the determinant by the rows with $p(0), p'(0),\dots p^{(k)}(0)$), I came up with the $(k+1)\times (k+1)$ determinant : $$ \begin{pmatrix} 1 & 1 & \cdots \cdots & 1\\ 2k+1 & 2k & \cdots \cdots& k+1 \\ (2k+1)\cdot2k & 2k\cdot(2k-1) & \cdots \cdots&(k+1)\cdot k \\ \vdots & \vdots & \vdots & \vdots &\\ \vdots & \vdots & \vdots & \vdots &\\ (2k+1)\cdot2k\cdots(k+2) & 2k\cdot(2k-1)\cdots(k+1) & \cdots \cdots&(k+1)\cdot k \cdots2\\ \end{pmatrix} $$
I do not know how to compute this determinant (is it a special one?)or at least show that it is not zero. Any suggestions are appreciated.
Let us consider the map: $u\in F_{\leq 2k+1}[X]\to F^{2k+2}$ sending $p$ to $(p(0),\ldots, p^{(k)}(0),p(1),\ldots,p^{k}(1))$, where $F$ is your prefered base field.
The map $u$ is linear, and you want to prove it is bijective. For, it is enough to prove its injectivity, since the source space and the target same have same dimension $2k+2$.
But $p\in\ker(u)$ means that $0$ and $1$ are roots of $p$ with multiplicity at least $k+1$ (maybe we need the characteristic of $F$ to be zero, here) , meaning that $p$ is a multiple of $x^{k+1}(x-1)^{k+1}$. This is not possible since the degree of $p$ is at most $2k+1$, unless $p=0$, and we are done.
Remark. As a consequence, you get that your determinant is indeed nonzero.