Assume I have a universe of N elements.
The question is: How many sets of size $X$ are needed to assure that every set of K elements is a subset of (at least) one of these sets (where $K \ll X \lt N$). And also, how can these sets be chosen to obtain this minimum?
In particular, the sizes that interest me are: \begin{align*} N &= O(2^{n^{c_1}}),\\ X &= O(2^n),\\ K &= O(n^{c_2}), \end{align*} where $n$ is a variable, $c_1$ and $c_2$ are constants.
Are covering numbers what you had in mind? Their (v,k,t) corresponds to your (N,X,K), if I'm not mistaken. Generally these covering numbers are very hard to compute, even for moderate values of (N,X,K). But perhaps asymptotic results are known that would help with the particular very large sizes that interest you.