Here is my little research:
$4=2^2$
$8=2^3$
$9=3^2$
$12=2^3+2^2$
$13=3^2+2^2$
$16=2^3+2^3$
$17=3^2+2^2+2^2$
$18=3^2+3^2$
$20=2^3+2^3+2^2$
$21=2^3+3^2+2^2$
$24=2^3+2^3+2^3$
and it seems every number $\ge 24$ is also representable as a sum of perfect powers (I checked up to 1000 using computer).
Is this known?
Any ideas how to prove it?
In a different direction from orlp's answer (now deleted): It seems you allow repeated powers. Assuming that exponents are required to be greater than or equal to $2$, observe that $2^2 = 4$ and $3^2 = 9$, and the Chicken McNuggets problem with $4$ and $9$ yields an upper bound of $4 \times 9 - 4 - 9 = 23$ for the numbers that cannot be expressed as a combination of those two numbers alone.
ETA: All other perfect powers of larger primes are $25$ or greater and therefore do not bear on this upper bound.