Parametrization of varieties

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I know that a variety $X$ that can be parametrized using rational functions is irreducible. My question is:

What can we get removing or replacing the hypothesis of $X$ being a variety by, for example, $X$ being a quasi-affine(projective) variety?

For example, using the stereographic projection, one can parametrize the $n$-dimensional sphere $S^n$ minus one point. That's a quasi-affine (irreducible) variety, since its the complement of a point in the variety $S^n$.

Is there a general result for these cases?