Suppose $F \subseteq K$ are fields. I'm trying to show that if $P,Q \in F[X]$ and $P \mid Q$ over $K$, then $P \mid Q$ over $F$ as well.
Denote the field of fractions of $F$ with $F(X)$. Then I have come to the point that it suffices to prove
$$F(X) \cap K[X] = F[X]$$
The inclusion $\supseteq$ is obvious. The other one should be straightforward, but I'm clearly forgetting something.
So, let $P \in F(X) \cap K[X]$, then $P = \frac{F_1}{F_2}$ with $F_1,F_2 \in F[X]$. I feel like this brings me back to where I started.
Other methods are appreciated as well.
Let $F$ be a field and $K$ an extension field.
Let $f,g\in F[X]$. Then the highest common factors of $f,g$ in $F[X]$ and $K[X]$ coincide. This is because if we carry out the classical Euclidean Algorithm on $f,g\in F[X]$ the h.c.f. and all the intermediate polynomials lie in $F[X]$. But this calculation (thought of as in $K[X]$) is just the Euclidean Algorithm in $K[X]$, and yields the same h.c.f.
Now suppose $p,q\in F[x]$ and $p|q$ in $K[X]$. Then $p$ is the h.c.f. in $K[X]$ of $p$ and $q$. Hence $p$ is the h.c.f. in $F[X]$ of $p$ and $q$. So $p|q$ in $F[X]$.