I am aware that principal $SU(N)$ bundles over 3-manifolds are trivial.
Consider, however, a principal $PSU(N)$ bundle over $\mathbb R^3$. Is the topology of this bundle classified by $$\pi_2(SU(N)/U(1)^{N-1})=\pi_1(U(1)^{N-1})=\mathbb Z^{N-1}$$? (The motivation for this hypothesis comes from the physics literature.)
Every fiber bundle over a contractible space is trivial. This is a consequence of the following result:
See Theorem $2.1$ of these notes for a proof.
If $B$ is contractible, then the identity map $\operatorname{id}_B: B \to B$ is homotopic to a constant map $c : B \to B$. So for any fiber bundle $p: E \to B$, we have $E \cong \operatorname{id}_B^*E \cong c^*E$ which is trivial.
To see that $c^*E$ is trivial, note that
$$c^*E = \{(b, e) \in B\times E \mid c(b) = \pi(e)\} = \{(b, e) \in B\times E \mid \pi(e) = b_0\} = B\times E_{b_0}$$
where $b_0$ denotes the constant value of the map $c$ and $E_{b_0} = p^{-1}(b_0)$. The projection map $B\times E_{b_0} \to B$ is just projection onto the first factor, so after choosing an isomorphism between $E_{b_0}$ and $F$, we obtain an isomorphism between $c^*E$ and the trivial bundle.