It is quite easy; suppose that there exist integers $a$ and $b$ such that $18a+6b=1$, then $6(3a+b)=1$, and that implies that $3a+b$ (which is an integer for any $a$ and $b$) is an multiplicative inverse of $6$. This is a contradiction, because the only integers with inverses are $1$ and $-1$.
It is quite easy; suppose that there exist integers $a$ and $b$ such that $18a+6b=1$, then $6(3a+b)=1$, and that implies that $3a+b$ (which is an integer for any $a$ and $b$) is an multiplicative inverse of $6$. This is a contradiction, because the only integers with inverses are $1$ and $-1$.