Full problem statement:
Prove that any two numbers of the follwing sequence are relatively prime:
$2 + 1, 2^2+1, 2^4 + 1, 2^8+1, ... 2^{2^n} + 1 $
So far I have tried to use Euclid's algorithm with mathematical induction. I have also proved that 3 is coprime to any number in the sequence, and have tried to use induction (using n = 0, i.e. 3, as the base case, and showing that the same property must be true for 5, 17, etc.)
Hint: Suppose that $m\lt n$. Then $2^{2^m}+1$ divides $2^{2^n}-1$. For let $x=2^{2^m}$. Then $2^{2^n}-1=x^{2^k}-1$, where $k=n-m$.
Remark: This result gives a nice proof that there are infinitely many primes. Let $F_n=2^{2^n}+1$, and let $q_n$ be the smallest prime divisor of $F_n$. Then by the result of the OP, all the $q_n$ are distinct.