$\Delta=\begin{vmatrix} \sqrt 6& 2i& 3+\sqrt 6 \\ \sqrt{12}&\sqrt 3 +\sqrt8i &3\sqrt 2 +\sqrt 6i \\ \sqrt{18} &\sqrt 2+ \sqrt {12}i &\sqrt {27}+2i \end{vmatrix}$
taking $\sqrt 6$ out from the first column and performing the following operations
$$R_2\rightarrow R_2 -\sqrt 2 R_1$$
$$R_3 \rightarrow R_3-\sqrt 3 R_1$$
$$\sqrt 6\begin {vmatrix} 1&2i&3+\sqrt 6 \\\ 0&\sqrt 3&\sqrt 6i-2\sqrt 3 \\\ 0&\sqrt 2&2i-3\sqrt 2 \end {vmatrix}$$
What should I do next?
From here
$$\sqrt 6\begin {vmatrix} 1&2i&3+\sqrt 6 \\\ 0&\sqrt 3&\sqrt 6i-2\sqrt 3 \\\ 0&\sqrt 2&2i-3\sqrt 2 \end {vmatrix}$$
Pull out a factor of $\sqrt{3}$ from the second row and a factor of $\sqrt{2}$ from the third to get
$$6\begin {vmatrix} 1&2i&3+\sqrt 6 \\\ 0& 1 &\sqrt 2i-2 \\\ 0& 1 & \sqrt{2}i-3 \end {vmatrix}$$
Now you can compute it easily by expanding along the first row or by subtracting the second row from the third. Lets subtract.
$$6\begin {vmatrix} 1&2i&3+\sqrt 6 \\\ 0& 1 &\sqrt 2i-2 \\\ 0& 1 & \sqrt{2}i-3 \end {vmatrix} = 6\begin {vmatrix} 1&2i&3+\sqrt 6 \\\ 0& 1 &\sqrt 2i-2 \\\ 0& 0 & -1 \end {vmatrix}$$
The determinant is just the product of the diagonal entries, so $6 \cdot 1 \cdot 1 \cdot -1 = -6$.