I need solution check to see if I overlooked something:
If $x^4+y^4=z^2$ has an integer solution then $(\frac{x}{y})^4+1=(\frac{z}{y^2})^2$ has a solution in rationals.
Second equation is equivalent to $X^4+1=Y^2$ which can be written as cubic Weierstrass form $$v^2=u^3-4u$$ where $u=\frac{2(Y+1)}{X^2}$ and $v=\frac{4(Y+1)}{X^3}$. By using SAGE we can see that Mordell-Weil group of this elliptic curve is empty (SAGE returns empty set, but I'm not sure if that is enough to conclude this), so we can conclude that there are no rational solutions to the second equation and no integer solution to the first one.
edit: No integer solution in positive integers.
SAGE 6.7 implements an algorithm due to Peth, et al. (See A. Peth, H. G. Zimmer, J. Gebel, E. Herrmann, Computing all S-integral points on elliptic curves, Math. Proc. Camb. Philos. Soc. 127 (1999), No.3, 383-402) which is considered robust. I've had papers accepted which invoked SAGE, and it was trusted with finding all the integer points on the elliptic curves. So the answer to your question is "Yes". But of course, some reader may have doubts.