The statement in the title is obviously wrong, with an easy counter example being any real submanifold of odd dimension.
My question is more specific: say I have a complex manifold $X$ with a real submanifold $M\cong S^2$, where $S^2$ is the $2$-dimensional sphere with its usual differentiable structure. Does it follow that $M$ is a complex submanifold of $X$?
I feel that this is true, since the real structure of $S^2$ coincides with its usual complex structure. But I'm not exactly sure since I wasn't able to produce a clean argument for this.
Definitely false. Think of $\Bbb C^2 = \{(z_1,z_2)\}$, and write $z_j=x_j+\sqrt{-1}y_j$. Consider the $(x_1,x_2)$-plane. This is not a complex subspace of $\Bbb C^2$, so certainly not a complex submanifold.
You can compactify this to $S^2\subset\Bbb CP^2$, if you so desire.