Can a (commutative) ring $S$ fail to have unique factorization but be a subring of a (possibly noncommutative) ring $R$ which does have unique factorization?
The idea being that the irreducibles in $S$ split further when viewed as a subring of $R$, thus somehow recovering unique factorization. It probably makes sense to require that the notion of unique factorization in $R$ reduces to the one in $S$.
Take any domain which is not a UFD; then it is a subring of its field of fractions, which is a UFD.