Whenever we take the inverse, and both sides are either positive or both sides are negative then the inequality sign reverses; (if one is side is positive and one side is negative, then the sign stays the same.)
Whenever we multiply both sides by $-1$, the inequality sign reverses too.
Since you don´t know whether x is positive or negative, you need to consider both scenarios.
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If $x \in \mathbb{R}$, then
$\frac{1}{x} < -\frac{1}{5}$ iff $x > -5$ and iff $-x < 5$.
If you are seeking after the rule of thumb, here it is: whenever we take inverse of both sides, the inequality sign reverses; whenever we multiply both sides by $-1$, the inequality sign reverses too.
Whenever we take the inverse, and both sides are either positive or both sides are negative then the inequality sign reverses; (if one is side is positive and one side is negative, then the sign stays the same.)
Whenever we multiply both sides by $-1$, the inequality sign reverses too.
Since you don´t know whether x is positive or negative, you need to consider both scenarios.