Claim: $S_3$ is soluable but not nilpotent
Proof: $S_3 \cong D_6$. $D_6$ has a subgroup of order 3 generated by the rotations, $\langle r\rangle$.
$|\frac{D_6}{\langle r\rangle}|=2$ so $\langle r\rangle \triangleleft D_6$.
Furthermore, $\frac{D_6}{\langle r\rangle} \cong \mathbb{Z}_2$, and $\langle r\rangle \cong \mathbb{Z}_3$,
Therefore we have an abelian series:
$1 \triangleleft \langle r\rangle \triangleleft D_6$
And thus $S_3$ is soluable.
I would be interested in somebody showing me a different way to do this, perhaps in terms of the derived series.
Now, $S_3$ is not nilpotent because $Z(S_3) = \{1\}$
To use the derived series:
Consider the presentation $D_3=\langle r,\bar{r}\mid r^3=\bar{r}^2=1, \bar{r}r=r^{-1}\bar{r}\rangle$. Note that $D_3'=\langle r\rangle$: since $$ [r,\bar{r}]=r^{-1}\bar{r}^{-1}r\bar{r}=r^2\bar{r}r\bar{r}=r^2r^{-1}\bar{r}\bar{r}=r $$ and similarly other commutators all in $\langle r\rangle$. So the derive series starts $$ D_3\unrhd D_3'\cong C_3 $$ and now $C_3$ is abelian, so its derived subgroup is trivial.