seeking for a general strategy to identify the right space for the domain of semigroup generator

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I wish to show the domain of a strongly continuous semigroup $S(t)$ is some sobolev space, for instance, for the heat semigroup, it is known that $$D(A)=W^{2,p}$$

I believe a general strategy to get above would be to show $$D(A)\subseteq W^{2,p},$$ and $$W^{2,p}\subseteq D(A) $$ However I am uncertain about how to achieve the above in detail, would be appreciate if anyone could outline me some steps to prove things like $D(A)=W^{2,p}.$