Problem: Let $F$ be a finitely generated free group. Prove that there is an $n$ manifold, $M$, $n > 2$ with $\pi(M) = F$.
Let $F = F_S$ s.t. $|S| \in \mathbb{N}$.
If I could show that there exists $n$-manifolds $M_1, \ldots , M_k$ s.t.
\begin{equation} \tag{*} F_S = \pi_1 (M_1) \ast \pi_1(M_2) \ast \ldots \ast \pi_1(M_k) \end{equation}
then I could use the result from this post to assert that
$$ F_S = \pi_1 (M_1) \ast \pi_1(M_2) \ast \ldots \ast \pi_1(M_k) = \pi_1(M_1 \# M_2 \# \ldots \# M_k) $$
so that if $M_1 \# \ldots \# M_k = M$, then we would have that $F_S = \pi_1(M)$ as desired.
Unfortunately, I'm not sure how we could show $(*)$, or if this is the right track towards an answer.
Let's start by constructing an $n$-manifold $M_n$ with $\pi_1(M_n) \cong \Bbb Z$. We know that $S^1$ is a $1$-manifold and $\pi_1(S^1) \cong \Bbb Z$. The product of two manifolds is again a manifold. Consider $M_n = S^1 \times \Bbb R^{n-1}$. This is an $n$-manifold. Since $\Bbb R^{n-1}$ is contractible, $\pi_1(M_n) \cong \pi_1(S^1) \times \pi_1(\Bbb R^{n-1}) \cong \Bbb Z$.
Now, we use the following result:
You can find a proof here.
What's left is to take the connected sum of $k$ copies of $M_n$, where $k$ is the number of generators of the given free group.