Here's what I tried:
Let the roots be $a$, $b$, $c$ and $d$, $a+b=4$. Then,
$$a + b + c + d = 8 \Longrightarrow 4 + c+ d = 8 \Longrightarrow a+b = c+d = 4$$ $$(a + b)(c + d) + ab + cd = 21$$ $$ab (c + d) + cd (a + b) = 20 \Longrightarrow 4ab + 4cd = 20 \Longrightarrow ab + cd = 5$$ $$abcd = 5$$
I can't figure out how to proceed.
$x^4-8x^3+21x^2-20x+5=(x^2-4x+a)(x^2-4x+b)$
$\begin{cases}a+b+16=21 \\ -4a-4b=-20\\ ab=5 \end{cases}$
So $a+b=5$ and $ab=5$.
$a$, $b$ are the roots of $t^2-5t+5=0$.