I have the IVP:
$$2yy'+5 = y^2 + 5x; y(0)=6.$$
In order to solve this, I have attempted to make the substitution $u = y^2 \implies \sqrt{u} = y$. However, I am not sure how to solve for $u'$, so I don't know how to proceed in the problem.
I know that $\frac{du}{dx} = \frac{d(y^2)}{dx}$ but I'm not really sure what that means or how to deal with it.
If $u = y^2$, then by the chain rule $$ u' = (y^2)' = 2yy'. $$ From your original equation, you see that $$ 2yy' = y^2+5x-5 = u+5x-5, $$ so that the equation for $u$ becomes $$ u' = u+5x-5. $$ Also take care that the initial condition for $u$ then becomes $$ u(0) = y(0)^2 = 6^2 = 36. $$