The coordinate matrix of x y z is known, and a three-dimensional space curve is drawn according to x, y, z. Now how to find the slope of each point

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The coordinate matrix of x y z is known, and a three-dimensional space curve is drawn according to x, y, z. Now how to find the slope of each point。The specific x y z coordinates are as follows x=[16.6604388065247 16.6606832173864 16.6607266351292 16.6605424175751 16.6600604626046 16.6595955496176 16.6612428860471 16.6634323822435 16.6615411941684 16.6589638601973] y=[121.069863759802 121.473750388985 121.878623860885 122.282878779977 122.676941113792 123.049481493681 123.414472784624 123.778030208679 124.131433687658 124.478800249564] z=[0 0.125000000000000 0.250000000000000 0.375000000000000 0.500000000000000 0.625000000000000 0.750000000000000 0.875000000000000 1 1.12500000000000]