I have this wooden puzzle composed of 25 y-shaped pentominoes, where the objective is to assemble them into a 5x5x5 cube. After spending quite a few hours unsuccessfully trying to solve the puzzle, I finally gave up and wrote a program to try all possible combinations using backtracking. Analyzing the results revealed that for every solution found, the computer made - on average - 50 million placements and removals of pieces. This is obviously beyond my capabilities as a human, even if I can see a few steps ahead that a partial solution leads to a "dead end".
So, my question is this: given that the puzzle is so symmetrical, is there some way to significantly prune the search tree (maybe even making it possible for me to solve the puzzle on my own)?

(sorry for the poor quality)

First, a few thoughts about this specific box packing problem. It might be possible to pack this box by packing the "y" polycube into 25 cells in 5 identical layers. This corresponds to collapsing this 3-D shape into a polyomino in the plane, and then using it to pack a 5x5 rectangle. However, this polyomino can not tile a 5x5 rectangle. (The terminology for polyominoes is not totally standard but some use the order of a polyomino to mean the smallest number of copies of this shape to tile a rectangle with congruent copies of itself.) The order of this polyomino is 10.
Second, there is lots of material about polyominoes and to a lesser extent box packings in the books:
S. Golomb, Polyominoes: Puzzles, Patterns, Problems, and Packings (Revised Edition), Princeton U. Press, 1994.
G. Martin Polyominoes, MAA, 1991.
Third, there are a variety of papers related to polyominoes and boxes at Michael Reid's very nice site with links to others:
http://www.math.ucf.edu/~reid/Polyomino/
http://www.math.ucf.edu/~reid/Research/index.html
Fourth, there are "complexity" results which govern the general problem of given a collection of tiles (either in 2-D or 3-D) when can one use them to tile some particular shape (say a rectangle or rectangular box). Here is a paper related to this of Erik Demaine:
http://erikdemaine.org/papers/Jigsaw_GC/
Also see:
http://archive.ite.journal.informs.org/Vol5No3/Chlond/index.php