Are there positions of the Rubik's Cube which cannot be reached by applying the standard moves starting from the solved cube? If so, how many such positions are there?
Unreachable rubik cube positions.
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Yes, there are. These arise from to quick observations: pieces move as part of a $3\times 3$ cube, not as individual faces, and center cubes must stay in the center, which is also true with corner pieces and side faces. Without loss of generality you can fix the center pieces, and then there are $8$ corner pieces $12$ side pieces. This gives us a maximum of $$8!12!=19313344512000$$ However I'm sure there are many fewer reachable positions than this, as pointed out in the comments. But this number already shows how many fewer positions this is the the overall number of permutations of 26 cubes: $$\frac{8!12!}{26!}=\frac{1}{20881492632000}$$ which is obviously a pretty small number. Obviously this isn't nearly exhaustive, but I hope this helps (also, I completely ignored changing orientation, which can definitely happen).
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I think a better way to ask your question would be to ask if there are configurations of the colored stickers, if you peel them off and move them, that don't correspond to cube positions reachable from the solved position by standard moves (or conversely are not solvable starting positions), and the answer is an emphatic "yes" -- for example, if you take the two stickers on one of the edge pieces and reverse them, the resulting cube is unsolvable. I don't have any numbers, but I suspect that the number of unsolvable configurations of the stickers is several orders of magnitude higher than the number of solvable configurations.
11 out of 12 random positions are unreachable.
This first part just looks at the positions of cublets, without regard to their orientation.
It is possible to place the corners in all $8!$ position permutations. Separately, it is possible to place all edge pieces in all $12!$ position permutations. But it is not possible to apply a permutation that swaps only two corners or two edges.
This is easily seen. All possible permutations arise from the application of 6 basic permutations corresponding to quarter-turns on each face. Each of these quarter-turns cycles 4 corners (an odd permutation, equivalent to 3 swaps, an odd number) and 4 edges (also an odd permutation). The combination of these two cycles is an even permutation (3+3=6 swaps, an even number), so any series of basic moves also results in an even permutation. This sets an upper bound of $\dfrac{8!12!}{2}$ position permutations.
It is possible to construct permutations that solely cycle the positions of 3 corners or 3 edges, so using these 3-cycles you can independendly reach all $\dfrac{8!}2$ even corner permutations and $\dfrac{12!}2$ even edge permutations, resulting in $\dfrac{8!12!}{4}$ total even position permutations. Turning one face throws both the corners and edges into odd permutations, and from here using the 3-cycle moves you can reach all $\dfrac{8!12!}{4}$ odd position permutations. Add these together and you get a lower bound of $\dfrac{8!12!}{2}$ reachable position permutations, which meets the upper bound.
In the second part here I'm talking about changing the orientations of the cubes, without changing their positions.
Corner rotations:
Moves exist that jointly counter-rotate any two corner pieces without affecting any other changes. This sets a lower bound of $3^7$ possible rotations of the corner pieces.
Consider a rotation labeling system for the corner cubes. Mark one facelet of each corner as special. Each corner cubelet position has a face whose normal points upward or downward, and call this position 0, the one clockwise from it 1, and the next clockwise 2. You will find that each basic move preserves the sum of these orientation numbers modulo 3, which sets an upper bound of $3^7$ possible corner orientations.
Edge rotations:
Move sequences exist that jointly flip any two edge pieces without affecting any other changes. This sets a lower bound of $2^{11}$ possible rotations of the edge pieces.
If you put together an arbitrary orientation numbering system like the corner orientation numbering system above, you'll find that all basic moves preserve the sum of orientations modulo 2. This sets an upper bound of $2^{11}$ possible rotations of the edge pieces.
So the cube in total has $\dfrac{8!12!2^{11}3^{7}}{2}$ permutations reachable through basic moves.
If you disassemble a cube you can place the corners in any of $8!$ position permutations and $3^8$ orientations, and the edges in any of $12!$ position permutations and $2^{12}$ orientations. This totals to $8!12!2^{12}3^{8}$ possible configurations, which means 11 out of 12 potential configurations are not reachable through basic moves.