What is $\Omega$ in the context of Poisson's equation?

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I have recently started a new course on PDE's and have already stumbled on an example that I'm struggling to understand:

Poisson

The main aspect of this example that I am struggling to wrap my head around is not in the proof, it's in the way that $\Omega$ is used in the second and third lines.

Does $\Omega$ denote the solution space? i.e. Does $\Omega = (x,y,z)$ and $\partial \Omega = (\partial x , \partial y , \partial z)$ (if the problem is to be solved in 3 dimensions)?

Furthermore, if it is the case that $\Omega$ denotes the solution space for the problem, why is $\partial \Omega$ the boundary of the solution space?

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For PDEs, it is very common to denote the domain of the PDE with $\Omega$.

Common examples are a circle/ball $$ \Omega = B_1(0) := \{ x\in \mathbb R^n : \|x\| < 1 \} $$

or a square $$ \Omega = (0,1)\times (0,1) $$

In this case $\partial\Omega$ denotes the boundary of the domain, and not partial derivatives! For example, in the case of $\Omega=B_1(0)$ we have $$ \partial\Omega = \partial B_1(0) := \{ x\in \mathbb R^n : \|x\| = 1 \} $$