The power-free natural (asymptotic) density of $x^k$ is $1/\zeta(k)$ plus error terms.
I suppose this means that the number of integers less than $N$ that a have $k$ power in their factorization is:
$N(1-1/\zeta(k))$ plus error terms.
So, what is the asymptotic density of $x^k+y^l$?
Not a complete answer but a trivial lower bound. Too long to be a comment.
Let $f(x)$ be the number of positive integers $\le x$ which can be expressed as the sum of two powers. Then,
$f(x) > $ number of positive integers $\le x$ which can be expressed as the sum of two squares
or $f(x) > $ number of primes $\le x$ which can be expressed as the sum of two squares
or $f(x) > $ number of primes $\le x$ which are of the form $4k+1$.
Hence by Dirichlet theorem of primes in arithmetic progression,
$$ f(x) > \frac{x}{2\log x}. $$