What is the maximum number of significant bits lost when the computer evaluates x − y using IEEE 64 bits?

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Consider two positive numbers $x = p2^m$ and $y = q2^n$ such that $m > n$, $1 < p < 2$, and $1 < q < 2$. Both of these numbers can be stored using the IEEE 64 bit standard.

What is the maximum number of significant bits lost when the computer evaluates $x − y$?