So, I was looking at the definition for the $H_0^1(\Omega)$ space, and I was wondering that if $\Omega = \mathbb{R}$.
This is really to embed the boundary conditions of my operator, $\mathcal{L}$ which is posed on the real line, but also has conditions such that for $\frac{du}{dt} = \mathcal{L}u$, $u \longrightarrow 0$ as $x\longrightarrow \pm \infty$.
For the space $H_0^1(\Omega)$, the norm is given by $||\frac{du}{dx} ||_{L^2}$, but this norm is motivated using Poincare's inequality that I am not sure can be used on the entire real line? On wikipedia for Poincare's inequality, it says that it must be bounded in at least one direction.
Results that $H^1_0(\Omega)=\overline{C^{\infty}_0(\Omega)}^{\|\cdot\|_1}$, where $\|\cdot\|^2_1 :=\|\cdot \|^2_{L^2}+\|\nabla \cdot \|^2_{L^2}$. But, $C^{\infty}_0(\mathbb{R}^n)$ is dense over $H^1(\mathbb{R}^n)$ (it requires convolution theory) so in this limit case $H^1(\mathbb{R}^n)=H_0^1(\mathbb{R}^n)$. See H.Brezis Functional Analysis, Sobolev Spaces and Partial Differential Equations, chapter 9 pp 287.