A question occurred to me when browsing SE this evening, just curious.
What specifies the inside of a 3D construct? If I have a hollow sphere, what's to say that the world isn't the inside, and the center of the sphere isn't the outside. Picture the Asylum in the Hitchhiker's Guide to the Galaxy series, if you have read that.
Additionally, if the inside of a 3D object is defined as what is smaller than the outside, what happens when there is a a sphere with a volume equivalent to 51% of the universe?
Mathematically speaking, when we talk about a two dimensional manifold embedded in 3-space (like the hollow sphere you're talking about), we have the assumption that the universe is unbounded. Thus, the surface acts as the boundary for a bounded interior and an unbounded exterior, and it's that bounded/unbounded distinction that defines which is the inside and the outside.
For the two dimensional case of this proof, and the higher dimension analogues, see http://en.wikipedia.org/wiki/Jordan_curve_theorem