I am looking for a set of positive integers $(\mathbb{S} \space\subset\space \mathbb{N} := \{1,2,3,...\})$ such that its "2-element quotients" are dense over the full set of positive rational numbers (which would also make it dense over the full set of positive real numbers).
One obvious satisfying set is $\{An+B \space\space|\space\space n\in\mathbb{N}\}$ where $A$ and $B$ are any given positive integers.
What about higher powers ($C$ is a given integer greater than 1) or square-free numbers?
$$\{An^C+B \space\space|\space\space n\in\mathbb{N}\}$$ $$\{\prod _{primes} {p^{b_p} \space\space|\space\space b_p \in \{0,1}\}\}$$
By the way, I believe I could eliminate any finite number of elements from any satisfying set and still have a satisfying set, so I am really thinking about the set's "asymptotic form".
Say $\mathbb{S}\subset\mathbb{N}$ has the dense rational property if the image of $\div:\mathbb{S}\times\mathbb{S} \rightarrow\mathbb{R}^+$ is dense. Let $s_n$ be the enumeration of $\mathbb{S}$, in increasing order. Then:
Claim: $\mathbb{S}$ has the dense rational property if $$ \lim\limits_{n\rightarrow\infty} \frac{s_n}{s_{n+1}}=1 $$ In particular, any set with a natural density has the dense rational property, including the square-free numbers. Also, the images of polynomials have the dense rational property, as do the prime numbers.
Conversely, $\mathbb{S}$ does not have the dense rational property if $$ \limsup\limits_{n\rightarrow\infty} \frac{s_n}{s_{n+1}} < 1 $$
Proof: Suppose $\limsup\limits_{n\rightarrow\infty} \frac{s_n}{s_{n+1}} < 1$. Then, there exists $R<1$ and $N\in\mathbb{N}$ such that $n\ge N$ implies $$ \frac{s_n}{s_{n+1}} < R $$ Thus for any $n>m\ge N$, we have $$ \frac{s_m}{s_n} < R^{n-m} \leq R $$ and $$ \frac{s_n}{s_m} > R^{m-n} \geq R^{-1} $$ hence the intersection of $\mathbb{S}\div \mathbb{S}=\left\{\frac{s}{t}\mid s,t\in\mathbb{S}\right\}$ has a finite intersection with the interval $[R,R^{-1}]$, and therefore cannot be dense.
Conversely, suppose $$ \lim\limits_{n\rightarrow\infty} \frac{s_n}{s_{n+1}} = 1 $$ It suffices to show that $\mathbb{S}\div \mathbb{S}$ is dense in $(1,\infty)$, since it is closed under taking reciprocals, and thus it suffices to show that for any $(a,b)\subset(1,\infty)$, there exist integers $n_1,n_2$ such that $$ \frac{s_{n_1 + n_2}}{s_{n_1}} \in (a,b) $$ Let $n_1$ be such that $n\ge n_1$ implies $\frac{s_{n + 1}}{s_{n}} < \frac{b}{a}$. Then, we observe that $$ \lim_{n\rightarrow\infty} \frac{s_{n_1+n}}{s_{n_1}} = \infty $$ Then we can define $$n_2 = \max\left\{n \text{ }:\text{ } \frac{s_{n_1+n}}{s_{n_1}} < b\right\} $$ Trivially, $\frac{s_{n_1+n_2}}{s_{n_1}} < b$ and $\frac{s_{n_1+n_2+1}}{s_{n_1}} \ge b$. We also have \begin{eqnarray} b&\le& \frac{s_{n_1+n_2+1}}{s_{n_1}} = \frac{s_{n_1+n_2}}{s_{n_1}} \cdot \frac{s_{n_1 + n_2+1}}{s_{n_1 +n_2}} < \frac{s_{n_1+n_2}}{s_{n_1}}\cdot \frac b a\\ a &<& \frac{s_{n_1+n_2}}{s_{n_1}} \end{eqnarray} as desired.