when did a codimension 2 manifold be intersection of two codimension 1 manifold?

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Say let $M$ be an codimension 2 submanifold of $N$, when do we have $M=M_1\cap M_2$, s.t. $M_i$ are codimension 1 submanifold intersecting transversally?

My guess is if $M$ is a knot and $N=S^3$, this condition do not holds. do we have a characterization for this?