If $b, c$ are integers, and $\sqrt{2} + \sqrt{3}$ is a root of the equation, $x^4 + bx^2 + c = 0$, which is greater, $b$ or $c$; where $b, c$ are both integers.
Since $\sqrt{2} + \sqrt{3}$ is a root, sub it in gives:
$ (5 + 2\sqrt{6})b + c = -49 - 20\sqrt{6}$
This gives:
$$c = -49 - 20\sqrt{6} - (5 + 2\sqrt{6})b$$
$$b = \frac{-49 - 20\sqrt{6} - c}{5 + 2\sqrt{6}}$$
If $c > 0$ then $b < 0$ and if $b > 0$ then $ c < 0$.
So how to go about this?
I know that $\sum \text{roots} = 0$ hence, WLOG, $r_2 + r_3 + r_4 = -\sqrt{2} - \sqrt{3}$, but that doesn't help.
$$\begin{align}x=\sqrt 2+\sqrt 3&\Rightarrow x-\sqrt 2=\sqrt 3\\&\Rightarrow x^2-2\sqrt 2x+2=3\\&\Rightarrow 2\sqrt 2x=x^2-1\\&\Rightarrow 8x^2=x^4-2x^2+1\\&\Rightarrow x^4-10x^2+1=0\end{align}$$
So, $x^4-10x^2+1=0$ is an equation which has a root $x=\sqrt 2+\sqrt 3$.
Suppose that $x^4+px^2+q=0$ has a root $x=\sqrt 2+\sqrt 3$ where $p,q$ are integers such that $(p,q)\not=(-10,1)$. Then, we have $$(x^2=)\ 5+2\sqrt 6=\frac{q-1}{-10-p}.$$ The LHS is irrational, and the RHS is rational, which is a contradiction.
So, we have $b=-10,c=1$.