On page 33, Robert Goldblatt, Lectures on Hyperreals(1998):
Now it has been shown under certain set-theoretic assumption called continuum hypothesis the choice of $\mathcal F$ is irrelevant: All quotients of $\Bbb {R}^{\Bbb N}$ with respect to nonprincipal ultrafilters on $\Bbb N$ are isomorphic as ordered fields.
I don't know why this is true. It seems to me if we want to prove continuum hypothesis implies the unique hyperreal system, we have to show that, for any two free ultrafilters $\mathcal {F}_{1}$ and $\mathcal {F}_{2}$ on $\Bbb N$, there is an bijection $f: \Bbb N \to \Bbb N$ such that there it's also a bijection from $\mathcal {F}_{1}$ to $\mathcal {F}_{2}$. How to show this holds with $\bf CH$ and fails without it.
As bestian tang suggested, you can use approach similar to the one used here.
First, notice that any countable ultrapower of ${\bf R}$ has cardinality continuum, so any two such ultrapowers are equipotent.
Then, by standard argument, a countable ultrapower of any structure in a countable language is $\aleph_1$-saturated (you can just recursively construct an element realizing a given type), so under CH, any countable ultrapower of ${\bf R}$ is saturated.
Finally, it is a well-known result that any two structures which are saturated and have the same cardinality are isomorphic (by a standard back-and-forth argument), so any two countable ultrapowers of ${\bf R}$ are isomorphic.
I don't think this approach will work for the whole hyperreal construction (with all real sets, relations, functions), as the language will, in this case, have cardinality strictly larger than ${\mathfrak c}$