One of the rules of powers is that you can multiply higher powers to each other: $2^{2^3}=2^6$.
Therefore, $2^{2^{-1}}$ should equal $2^{-2}$?.
But according to wolfram alpha, $2^{2^{-1}} = 2^\frac{1}{2}$.
Do the rules of power change when a negative sign is present? Does taking the inverse take priority over multiplication?
It depends on where you put the parentheses. In fact $2^{2^3}= 2^8$ is different that $(2^2)^3=2^{6}$. If it is lacking parntheses, you should evaluate from top to bottom.