My progress so far:
$2^{\sin(x) + \cos(y)} = 1$
$16^{\sin^2(x) + \cos^2(y)} = 4$
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$\sin(x) + \cos(y) = 0$
$\sin^2(x) + \cos^2(y) = \frac12$
I think I'm on the right track, but I'm not sure how to continue. Thanks in advance to anyone who helps.
Suppose $\sin x + \cos y = 0$. Then $$\sin ^2x + \cos ^2y = (\sin x + \cos y) ^2 -2\sin x\cos y = -2\sin x\cos y. $$ Thus we have left to consider $$\begin{cases} \sin x + \cos y = 0 \\ \sin x\cos y = -\frac{1}{4} \end{cases} $$ Can you take it from here?