Mitchell's Theory of Categories defines locally small category as the following. Let $C$ be a category and $A\in Obj(C)$. Denote $S=\{[B]\subset A\}$ as the class of equivalent subobjects of $A$. If $S$ is a set, then one calls $C$ a locally small category. (It seems that this is a stronger requirement than the wikipedia's locally small category which only requires Hom sets as sets.)
The point is to look for a category $C$ which is locally small but its subcategory $C'$ is not locally small.
There are 2 cases I want to distinguish to allow $C'$ not locally small.
There are more monomorphisms in $C'$ than $C$
The two mono maybe isomorphic in $C$ but not in $C'$.
$\textbf{Q:}$ What are corresponding example of $C,C'$ in case 1 and case 2 separately? It seems I need to somehow run into russel paradox type construction but I do not see the obvious examples. However, if $C$ is a set category, there is no way I can get 1 to work. My guess for 2 would be considering $C$ to be set category and to get $C'$ not locally small via 2, I need to delete enough invertible elements to generate more than enough inequivalence classes but I am not sure cardinality will work out in general.
First some terminology. Wikipedia's definition of locally small is the usual one (so every $\operatorname{Hom}(A, B)$ is a set), and what you are talking about is usually referred to as well-powered. This is also the terminology I will use in this answer. Neither of those imply the other. In fact, one of the examples below is locally small, but not well-powered (example 2). It should also be clear that in this sense every subcategory of a locally small category is locally small.
So your question is then: can we make a well-powered category into a non well-powered category by deleting arrows such that either
We can do the following for each case.
You can also combine these two approaches to get examples. Might be nice to think about that yourself.