A) $x^4+x+1\in \Bbb Z_2[x]$ is irreducible
Proof:
$x^4+x+1\in \Bbb Z_2[x]$ is primitive. The mod 2 reduction of $x^4+x+1\in \mathbb{Z}[x]$ is $f(x)=x^4+x+1\in \Bbb Z_2[x]$. Since $f(a) = 1 \neq 0$ for all $a\in\Bbb Z_2$ it follows that $f(x)$ has no linear factors. Suppose that $f(x)$ is reducible. Then it must be the product of quadratic factors. There are $3$ quadratic reducible polynomials in $\Bbb Z_2[x]$. The irreducible one is $x^2+x+1$ since this polynomial has no roots in $\Bbb Z_2$. Therefore $f(x)=(x^2+x+1)^2=x^4+x+1$ which is not the case. Thus it is irreducible.
B) $\displaystyle\sum_{i=1}^{42}x^{i-1} \in \Bbb Z_2[x]$ is irreducible
I was able to prove problem A which I needed your guidance which on whether or not it was true.
But how to prove problem B?
Cyclotomic polynomials are irreducible. It is elaborated here:
http://en.wikipedia.org/wiki/Eisenstein's_criterion