Statement: if $X$ is a finite path connected CW-complex, then $X$ is homotopy equivalent to a CW-complex with only one $0$-cell.
Thoughts: we can use the theorem that for a contractable subspace $A \subseteq X$ such that $(X, A)$ has the homotopy extension property, the projection $X \to X/A$ is a homotopy equivalence. I want to apply this for each $1$-cell that does not have its ends glued together. This is ok because then it is a contractable, there are only finitely many, so eventually this procedure will stop and $(X, A)$ is a relative CW-complex, so it has HEP.
We will be left with only $1$-cells that have their ends glued together. I'd like to conclude from path connectedness that there is only one $0$-cell left, but could not manage this.
Consider the $1$-skeleton $X^1$ of $X$. Since $X$ is path connected, the cellular approximation theorem shows that $X^1$ is path connected. We have finitely many $0$-cells $\{x_i\}$, $i = 1,\ldots,m$. Let us show how to reduce the number of $0$-cells by $1$ (if $m > 1$). There exists a path from $x_m$ to $x_1$. Hence there must exist a closed $1$-cell $e^1$ attached to $\{x_m\}$ and some $\{x_i\}$ for $i < m$. Clearly $e^1$ is a contractible subcomplex of $X$ (with $0$-skeleton $\{x_m,x_i\}$) , thus the quotient map $X \to X' = X/e^1$ is a homotopy equivalence. The space $X'$ is a path connected CW-complex. The number of $0$-cells is $m-1$. Thus, proceeding inductively, we get the desired CW-complex with one $0$-cell.
Edited:
The finiteness assumption can be omitted, the assertion is true for any path connected CW-complex.
In fact $X^1$ is a multigraph, i.e. a graph which is permitted to have multiple edges between two vertices (note that edges can be self-loops connecting a vertex to itself). It is well-known that each connected multigraph has a spanning tree which contains all vertices. Recall that a tree is a contractible subgraph. See for example Hatcher's "Algebraic Topology" Proposition 1A.1. So let $T$ be a spanning tree of $X^1$. It is a subcomplex of $X$, thus the quotient map $X \to X/T$ is a homotopy equivalence. The CW-complex $X/T$ has only one $0$-cell.