I've been trying to understand homomorphisms from a finite group $G$ into $\operatorname{PGL}(n,R)$ for $n$ a positive integer, and $R$ a commutative ring with 1, usually a field.
I had been under the impression that these were induced by homomorphisms from the Darstellungsgruppen of $G$ into $\operatorname{GL}(n,R)$, but I am having doubts.
What is wrong with the following example?
Take $G$ to be cyclic of order 2. Its Schur multiplier is trivial, so it is its own Darstellungsgruppe.
For $r \in R^\times$, set $a=\begin{bmatrix} 0 & 1 \\ r & 0 \end{bmatrix} \in \operatorname{GL}(2,R)$. Then $a^2 = r a^0 \in Z(\operatorname{GL}(2,R))$ so $\bar a$ has order 2 in $\operatorname{PGL}(2,R)$.
Consider the homomorphism from $G$ to $\operatorname{PGL}(2,R)$ that sends a generator to $\bar a$. This is not induced by any homomorphism from a covering group of $G$ to $\operatorname{GL}(2,R)$ as long as $r$ has no square root in $R$.
Indeed any such homomorphism is determined by where it sends a generator, say to $b$, and to induce the original homomorphism to PGL $\bar b$ must equal $\bar a$.
If $\bar b = \bar a$ then $$b=\zeta a = \begin{bmatrix} 0 & \zeta \\ \zeta r & 0 \end{bmatrix} \quad b^2 = \begin{bmatrix} \zeta^2 r & 0 \\ 0 & \zeta^2 r \end{bmatrix}$$ If we want $b$ to have order 2, then $\zeta^2 r = 1$ and $\zeta^2 = \tfrac{1}{r}$, so if $r$ has no square root in $R^\times$, there is no such $b$.
Even if we claim the Darstellungsgruppen is cyclic of order 4 (since $H^2(C_2, R^\times)$ is likely equal to $(R^\times)/(R^\times)^2 \cong C_2$) we still need $\zeta^2r = -1$, but if $-1$ is a square in $R$, then $-r$ also has no square root, and it is still a counterexample.
We have $H^2(G,R^\times) \cong {\rm Hom}(M(G),R^\times) \oplus {\rm Ext}(G/G',R^\times)$, where $M(G)$ is the Schur multiplier of $G$.
If $R^\times$ is divisible (which is true, for example, if $R$ is algebraically closed), then ${\rm Ext}(G/G',R^\times) = 0$, and all extensions arises from a homomorphism from $M(G)$ to $R^\times$, and any homomorphism $G \to {\rm PGL}(2,R)$ lifts to $\hat{G} \to {\rm GL}(2,R)$ for some covering group $\hat{G}$ of $G$. But in general this will not be the case.