Suppose $M$ is a compact smooth manifold with boundary, which is homeomorphic to the compact ball $\mathbb{B}^d\subset \mathbb{R}^d$. Must $M$ be diffeomorphic to $\mathbb{B}^d$ or are there exotic smooth structures?
I suspect that the answer is well known or might follow from a simple argument that experts (which I am certainly not) have up their sleeves.
A natural candidate in $d=4$ would be to take $M$ to be the compact unit-ball in an exotic $\mathbb{R}^4$, but I don't know how to check whether $M$ is exotic (or even whether it has a smooth boundary to be honest).
In dimension 4, one has the following equivalence:
Proof. We construct maps both ways, which will be clearly inverse.
$C: \mathcal B_4 \to \mathcal S_4$. Pick $B \in \mathcal B_4$. By the resolution of the 3D Poincare conjecture, there is some oriented diffeomorphism $\varphi: \partial B \to S^3$. One may then "cap off the boundary": define $$C(B) = B \cup_\varphi B^4,$$ defined as $B \sqcup B^4$, modulo identifying $\partial B \cong S^3$ via the diffeomorphism $\varphi$.
$C$ is well-defined by Cerf's theorem that $\pi_0 \text{Diff}^+(S^3) = 1$: all diffeomorphisms are the same up to isotopy. Isotoping $\varphi$ above does not change the diffeomorphism type; so $C$ is a set map.
Conversely one has $D: \mathcal S_4 \to \mathcal B_4$, with $D(S)$ given by deleting the interior of some oriented embedding $\iota: B^4 \to S$. Oriented embeddings of balls into a connected manifold are unique up to isotopy (Palais, but straightforward); this is true in all dimensions.
Clearly $D(C(B)) = B$ (delete the ball you glued) and $C(D(S)) = S$ (glue in the ball you deleted). Therefore $C,D$ are inverse bijections.
However one has the following for $n \geq 6$.
Proof: Pick $B \in \mathcal B_n$. Delete a standard ball from its interior; then we are provided with a compact manifold $W$, with $\partial W = S^{n-1} \sqcup \partial B$, so that $W \cup_{S^{n-1}} B^n = B$.
$W$ is an h-cobordism (algebra). Therefore by the h-cobordism theorem there is a diffeomorphism $W \cong S^{n-1} \times [0,1]$, which sends $S^{n-1}$ to $S^{n-1} \times \{0\}$ by the identity map. Therefore $W \cup_{S^{n-1}} B^n \cong B^n$. Therefore $B \cong B^n$.
Of course there are no exotic n-balls n = 1,2,3. For n=5 I do not know. I think the answer is that $\partial: \mathcal B_5 \to \mathcal S_4$ is an injection (maybe bijection?) but I don't know off the top of my head. Some googling or looking on Math Overflow should help. Obviously "exotic balls" will get you nowhere but some buzzwords like diffeomorphism might.