Let $X$ be a smooth projective variety over an algebraically closed field $k$ of characteristic zero.
Is there a description of $\operatorname{Aut}(\operatorname{Coh}(X))$, i.e. the autoequivalences of the category $\operatorname{Coh}(X)$?
Clearly it contains $\operatorname{Aut}(X)\ltimes\operatorname{Pic}(X)$ as a subgroup.
In fact, the story with autoequivalences of $\mathrm{Coh}(X)$ is much more simple than the story of $\mathrm{D}^b(X)$. Indeed, the structure sheaves of points of $X$ are intrinsically determined as simple objects of $\mathrm{Coh}(X)$ (i.e., objects that have no nontrivial subobjects). Therefore, any autoequivalence must take the structure sheaf of a point to the structure sheaf of another point. It follows that the bimodule over $\mathrm{Coh}(X)$ that gives the autoequivalence is a line bundle twist of the structure sheaf of a graph of an automorphism of $X$, hence the autoequivalence is a composition of an automorphism and a twist.