How can one determine the axis of symmetry of a generalised quartic in $x,y$ such as :
$$y-2x=(x+2y-1)(x+2y-2)(x+2y-3)(x+2y-4)$$
in particular if it is given in expanded form? This equation has been constructed from a nice upright symmetrical curve (which can be easily guessed by inspection) and then rotated. The objective is to see how the axis/axes of symmetry can be worked out from the equation.
$t=y-2x,u=x+2y$ define a similarity transform which restores the presumably original equation:
$$t=(u-1)(u-2)(u-3)(u-4).$$
By a further shift of $u$, on gets an even function
$$t=\left(v-\frac32\right)\left(v-\frac12\right)\left(v+\frac12\right)\left(v+\frac32\right)=\left(v^2-\frac14\right)\left(v^2-\frac94\right)=v^4-\frac52v^2+\frac9{16}.$$