Suppose $A\subseteq M_{n}(\mathbb{C})$ is a C$^{*}$-algebra acting irreducibly on the finite-dimensional space $\mathbb{C}^{n}$. I.e., there are no non-trivial subspaces of $\mathbb{C}^{n}$ invariant under $A$, or, equivalently, $W_{v}:=\operatorname{span}\{av:a\in A\}=\mathbb{C}^{n}$ for any $v\in\mathbb{C}^{n}$.
Is there a straightforward way to see that $A=M_{n}(\mathbb{C})$?
A unital C$^*$-algebra $A\subset M_n(\mathbb C)$ is of the form $M_{n_1}(\mathbb C)\oplus\cdots\oplus M_{n_k}(\mathbb C)$, with $n_1+\cdots+n_k=n$. If $k\ne1$, then $A$ has central projections, and thus it has invariant subspaces: for a central projection $p$, $$ a(px)=apx=pax\in p\,\mathbb C^n,\ \ \ a\in A,\ x\in\mathbb C^n, $$ and then $A(p\mathbb C^n)\subset p\,\mathbb C^n$. So the only way that $A$ may fail to have nontrivial invariant subspaces is when $k=1$, i.e. $A=M_n(\mathbb C)$.
If the unit $1_A$ of $A$ is not $I_n$, then $1_A$ is a central projection in $M_n(\mathbb C)$ and thus $A$ has nontrivial invariant subspaces.