I am seeking assistance in calculating the sum of a specific sequence of binomial coefficients: $1000 \choose 1$ + $1000 \choose 5$ + $1000 \choose 9$ + ... + $1000 \choose 997$. I have noticed that the terms in the sum follow the pattern $\sum_{k=0}^{249} \binom{1000}{4k+1}$. However, I am uncertain about the next steps in simplifying this expression. I am wondering if using the properties of binomial coefficients could be helpful. I have also attempted to use Vandermonde's identity, but I haven't been able to simplify the expression significantly.
Could someone provide guidance on which properties of binomial coefficients to apply or suggest an approach to calculate the sum effectively?
Notice that ${1000\choose997} = {1000\choose3}$. You can rewrite your sum as
$$\sum_{k=0}^{249} {1000\choose 2k+1}$$
Which is half of the odd terms of that row of Pascal's triangle. There are standard exercises to show that the sum of the all the odd terms is $2^{999}$, so your sum should be half of that $2^{998}.$