Can open and closed manifolds be combined in non-trivial ways?

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For example an infinite line and a circle. You can form a cross product which is an infinite tube.

What about a sphere and a plane? Can they be combined to form a manifold which is not a simple cross product of the two? What about higher dimensions such as $\mathbb{R}^4$ with $S_4$. Can they be combined so that the 8 dimensional manifold is not just the product of the two? Are there some examples.

I am thinking of the way, in group theory, SU(2) and SU(3) can be embedded in SU(5) which contains the cross product SU(2)xSU(3) but is not a simple cross product itself.

I wondered if open and closed spaces can be combined in non-trivial ways too?

(What got me thinking is that if the Universe is infinite and 4 dimensional and has some compact dimensions on a sphere, say, is the manifold always just the cross product of the open and closed spaces or can it be part of something more interesting?)